Murkowski resigned her role as vice chairwoman of the Republican Conference before announcing the write-in candidacy. The GOP leadership in Washington, D.C., led by Minority Leader Mitch McConnell (Ky.), backed Miller.
Murkowski has shown no inclination of interfering with McConnell in the way that Sen. Joe Lieberman (I-Conn.) has sometimes confounded Majority Leader Harry Reid (D-Nev.). Lieberman won re-election as an "Independent Democrat" after losing the 2006 Democratic Senate primary to Ned Lamont. Lieberman became a difficult vote for Reid to corral during the health care debate, when Reid need every one of the 60 votes in his caucus to overcome GOP opposition.
Akin could be different than either Lieberman or Murkowski, however. Those two were already in the Senate and familiar with the nature of the chamber. Akin has served only in the House, where the partisan divide has long been more pronounced.
Sean Theriault of the University of Texas at Austin and David Rohde of Duke University have studied the voting patterns of Senators and found that Representatives since 1978 who have later become Senators have been among the most predictably conservative during the past few decades.
"Almost the entire growth in Senate party polarization since the early 1970s can be accounted for by Republican senators who previously served in the House after 1978," the pair wrote in a paper. "In turn, our analysis indicates that the impact of these Republican former representatives can partially be accounted for by a set of constituency factors that are related to their increased conservative voting."
A group of Republicans, led by Blunt and former Missouri Sen. Kit Bond, has sounded conciliatory toward Akin without pledging financial support. On Sunday, Blunt indicated on CNN's "State of the Union" that the race was less about Akin and more about retaking control of the Senate.
Tea party favorite Sen. Jim DeMint (R-S.C.) is among those backing Akin, and the Senate Conservatives Fund run by DeMint supporters is committed to raising funds for his campaign.
Republicans would prefer to Akin prevail because it helps the path to a majority in the Senate, but they are not getting their hopes up.
National Republican Senatorial Committee Chairman John Cornyn (Texas) told the Louisville Courier-Journal, the hometown Kentucky paper of McConnell, last week that the NRSC was making "pretty much a business decision" to not put money into the Missouri race.
Roll Call shifted the race from Tossup to Leans Democratic when Akin stayed on the ballot past the final deadline to drop out.
McCaskill contends Akin's views are more out of step than just a set of unwise statements. That was her message in national cable interviews Friday.
"It's not what he has said that is the problem. It's what he believes that is the problem," McCaskill told MSNBC.
Reporters asked Akin on Friday in Kansas City about an arrest record from an anti-abortion protest decades ago.
"As I've made very clear, I don't apologize for being pro-life. I stand up for the things I believe in." Akin said, according to the Associated Press.
Former Sen. Scott Brown, R-Mass., candidate for U.S. Senate in New Hampshire, holds his hand over his heart during the singing of the national anthem as he waits to take the stage for his town hall campaign rally with Sen. John McCain at the Pinkerton Academy in Derry, N.H., on Monday, Aug. 18, 2014.