San Antonio Mayor Julian Castro also sought to paint Romney as out of touch, a rich man who does not understand the struggles of average Americans - in fact, the polar opposite of the man Michelle Obama would go on to represent in her husband.
Castro also held up the budget blueprint proposed by GOP vice presidential nominee Rep. Paul Ryan (Wis.) as the boogey man for the left.
"The Romney/Ryan budget doesn't just cut public education, cut Medicare, cut transportation and cut job training," he said. "It doesn't just pummel the middle class - it dismantles it. It dismantles what generations before have built to ensure that everybody can enter and stay in the middle class."
But it was someone who did not hold office who got one of the biggest reactions of the night.
"Women still earn just 77 cents for every dollar men make," Lilly Ledbetter, the namesake of the Fair Pay Act, said in her speech.
And then the audience roared with her follow-up.
"Maybe 23 cents doesn't sound like a lot to someone with a Swiss bank account, Cayman Island investments and an IRA worth tens of millions of dollars," she added.
Ledbetter was one of several speakers highlighting women's issues, and an entire segment of the program was dedicated to abortion, with Nancy Keenan, president of NARAL Pro-Choice America speaking.
A panel of House Democratic women led by Minority Leader Nancy Pelosi (Calif.) also took the stage to speak about how Medicare and veterans issues affect women.
"I'm Nancy Pelosi, but my grandchildren call me Mimi," she said. "For me, politics is an extension of my role as a mother and a grandmother. For the Democratic women of the House, our work is not about the next election but rather the next generation."
Senate Minority Leader Mitch McConnell, R-Ky., carries a musket on stage as he speaks during the American Conservative Union's Conservative Political Action Conference (CPAC) at National Harbor, Md., on Thursday March 6, 2014.