Why do these drugs cost so much?Its a question community pharmacists hear from patients on a regular basis and more frequently with the economic downturn. While community pharmacists can help some patients manage their prescription drug portfolios more economically, there is no easy answer.Some of the cost of medicine is tied up in research and development, clinical trials, and other costs related to bringing new medicines to market. Cuts in these areas cant be made without a commensurate reduction in health outcomes for patients.Other cost factors are ripe for savings and carry no downside for patients. Such is the case with the hidden fees and other costs imposed by the pharmacy benefit manager industry. PBMs are the middlemen hired to administer drug benefits on behalf of health plan sponsors, such as employers, unions and the government. These companies have swelled from sleepy claims processors to billion-dollar corporations, such as CVS Caremark, Medco Health Solutions, and Express Scripts, which reported a 20 percent increase in profits last year.A coalition of consumer groups, including the Consumer Federation of America, the U.S. Public Interest Research Groups and the National Legislative Association on Prescription Drug Prices, put it this way: PBMs represent the most rapidly growing segment of health care spending, and yet they are the only part of the health care market that is still unregulated. Because of the lack of regulation PBMs engage in fraudulent and deceptive practices, resulting in several enforcement actions by a coalition of state attorneys general that have secured over $371 million in fines and penalties.The growth of PBMs has been fueled by the ever-growing share of prescription drug transactions that they are allowed to retain. PBMs pay pharmacies one price for dispensing a drug, then charge the plan sponsor much more. Or they pocket large portions of discounts or rebates from drug manufacturers before passing the rest on to plan sponsors and patients. These and other practices inflate the health insurance premiums paid by patients and sponsors of health plans. These PBM clients are informed about very few, if any, of these arrangements, much less their massive scope. Without that transparency, its impossible to judge the return on the premium paid to pharmacy benefit managers. Fortunately, there are encouraging signs that such data could become more available. On Friday, the Senate Finance Committee voted unanimously to add to the health care reform bill an amendment authored by Sen. Maria Cantwell (D-Wash.). The National Community Pharmacists Association is grateful for Cantwells leadership, Chairman Max Baucus (D-Mont.) strong support and the votes of their colleagues.The Cantwell amendment would require PBMs to provide basic aggregate information in three key areas to facilitate educated decisions about which PBM, if any, offers the best value for health plans and patients: First, a breakdown of those prescriptions provided through retail pharmacies as well as mail-order pharmacies and the generic drug dispensing and substitution rates of each.